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Print Share Butterbur Scientific Name s: Gaertner, Meyer and Scherb. Asteraceae Aster Common Name s: Blatterdockbog rhubarbbogshornsbutter-dockbutterburbutterfly dockcoltsfootexwortfuki Japanesepestilence-wortpestwurz GermanPetadolexPetaforceTesalinZE Medically reviewed on Jan 11, Uses Commercial preparations derived from butterbur include Petadolex available in the United States sinceTesalinand Petaforce.
A few small clinical trials some open label have shown some benefit in the treatment of migraines and allergic rhinitis. Dosing Trials in migraine, allergic rhinitis, and asthma have used butterbur extracts in dosages ranging from 50 to 75 mg twice daily.
Tesalin 16 to 32 mg in divided doses has been used in allergic rhinitis. Trials have included subjects 6 years of age and older. Contraindications Consider the use of butterbur-containing preparations in congestive heart failure a relative contraindication because of negative chronotropic effects demonstrated in animal experiments.
Preparations may contain liver toxins with carcinogenic and mutagenic potential.
Interactions None well documented. Adverse Reactions GI symptoms comprise the majority of reported adverse reactions. Inhibition of testosterone production has been reported. Toxicology Pyrrolizidine alkaloids found in butterbur are known liver toxins with carcinogenic and mutagenic potential.
Commercial dosage forms must be free of hepatotoxic pyrrolizidine alkaloids.
Botany Butterbur is a perennial shrub native to Europe that has very large, downy leaves. It commonly grows in wet, marshy ground or on sandbars near streams. The distinctive pink-lilac flowers grow on large spikes and appear before the leaves in spring.
The name butterbur relates to the use of the leaves to wrap butter. During the Middle Ages, butterbur leaves and roots were used to treat cough, plague, and fever. Other traditional uses include the treatment of gastric ulcer and bee stings. High-performance liquid chromatography HPLC analyses of both plant parts indicate that, on average, leaves have lower alkaloid levels than roots.
The petasin series of compounds is unstable in storage, with rearrangements occurring in dry plant materials and in stored extracts. The biosynthesis of petasin has been elucidated. Both subjective and objective data serve as end points and measures of efficacy.
Dosages used in these trials range from Tesalin 16 to 32 mg in divided doses and Petadolex mg in adults, with durations of 7 to 14 days.Med-Surg Exam Study Guide Essay 1- Question: A client arrives in the emergency room complaining of chest pain that began 4 hours ago.
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